Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus.

ABSTRACT: Locus coeruleus (LC) projections to the hippocampus play a critical role in learning and memory. However, the precise timing of LC-hippocampus communication during learning and which LC-derived neurotransmitters are important for memory formation in the hippocampus are currently unknown. Although the LC is typically thought to modulate neural activity via the release of norepinephrine, several recent studies have suggested that it may also release dopamine into the hippocampus and other cortical regions. In some cases, it appears that dopamine release from LC into the hippocampus may be more important for memory than norepinephrine. Here, we extend these data by characterizing the phasic responses of the LC and its projections to the dorsal hippocampus during trace fear conditioning in mic

SUBMITTER: Wilmot JH 

PROVIDER: S-EPMC11003744 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature