Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.

ABSTRACT: The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process relies on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)^{1,2,3,4,5,6,7,8} and monitors internal state via interoceptive inputs from the hypothalamus and brainstem.³

SUBMITTER: Beas S 

PROVIDER: S-EPMC11003833 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature