Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13.

ABSTRACT:

Objectives

Disturbances of the central nervous system and immune system are thought to play a role in sudden infant death syndrome (SIDS). Dysregulated expression of sodium (Na⁺)/hydrogen (H⁺) exchanger 3 (NHE3) in the brainstem and of interleukin 13 (IL13) in the lungs has been observed in SIDS. An association of single-nucleotide polymorphisms (SNPs) in NHE3 and IL13 with SIDS has been proposed, but controversial results were reported. Therefore, there is a need to revisit the association of SNPs in NHE3 and IL13 with SIDS.

Methods

Genotyping of rs71597645 (G1131A) and rs2247114 (C2405T) in NHE3 and rs20541 (+ 4464A/G) in IL13 was performed in 201 SIDS cases and 338 controls. A meta-analysis was performed after merging our data with previously publish

SUBMITTER: Qu D 

PROVIDER: S-EPMC11003888 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature