Transcriptome analysis of Kluyveromyces marxianus under succinic acid stress and development of robust strains.

ABSTRACT: Kluyveromyces marxianus has become an attractive non-conventional yeast cell factory due to its advantageous properties such as high thermal tolerance and rapid growth. Succinic acid (SA) is an important platform molecule that has been applied in various industries such as food, material, cosmetics, and pharmaceuticals. SA bioproduction may be compromised by its toxicity. Besides, metabolite-responsive promoters are known to be important for dynamic control of gene transcription. Therefore, studies on global gene transcription under various SA concentrations are of great importance. Here, comparative transcriptome changes of K. marxianus exposed to various concentrations of SA were analyzed. Enrichment and analysis of gene clusters revealed repression of the tricarboxylic acid cycle and gl

SUBMITTER: Zeng DW 

PROVIDER: S-EPMC11003901 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature