Hyperpolarized [1-¹³C]-pyruvate MRS evaluates immune potential and predicts response to radiotherapy in cervical cancer.

ABSTRACT:

Background

Monitoring pyruvate metabolism in the spleen is important for assessing immune activity and achieving successful radiotherapy for cervical cancer due to the significance of the abscopal effect. We aimed to explore the feasibility of utilizing hyperpolarized (HP) [1-¹³C]-pyruvate magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) to evaluate pyruvate metabolism in the human spleen, with the aim of identifying potential candidates for radiotherapy in cervical cancer.

Methods

This prospective study recruited six female patients with cervical cancer (median age 55 years; range 39-60) evaluated using HP [1-¹³C]-pyruvate MRI/MRS at baseline and 2 weeks after radiotherapy. Proton (¹H) diffusion-weighted MRI was per

SUBMITTER: Lin G 

PROVIDER: S-EPMC11003947 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature