The role of stroke-induced immunosuppression as a predictor of functional outcome in the neurorehabilitation setting.

ABSTRACT: Stroke affects the interconnection between the nervous and immune systems, leading to a down-regulation of immunity called stroke-induced immunosuppression (SII). The primary aim of this study is to investigate SII role as a predictor of functional, neurological, and motor outcomes in the neurorehabilitation setting (NRB). We conducted a prospective observational study enrolling post-acute stroke patients hospitalized for neurorehabilitation. At NRB admission (T₀) and discharge (T₁), we assessed presence of SII (defined by a neutrophil-to-lymphocyte ratio ≥ 5) and we evaluated functional independence (Functional Independence Measure-FIM, Barthel Index-BI), motor performances (Tinetti Score, Hauser Ambulation Index) and neurological impairment (NIHSS). We enrolled 96 p

SUBMITTER: Vaghi G 

PROVIDER: S-EPMC11003970 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature