Sedentary lifestyle, physical activity, and gastrointestinal diseases: evidence from mendelian randomization analysis.

ABSTRACT:

Background

The causal associations of physical activity and sedentary behavior with the risk of gastrointestinal disease are unclear. We performed a Mendelian randomization analysis to examine these associations.

Methods

Genetic instruments associated with leisure screen time (LST, an indicator of a sedentary lifestyle) and moderate-to-vigorous intensity physical activity (MVPA) at the genome-wide significance (P < 5 × 10^-8) level were selected from a genome-wide association study. Summary statistics for gastrointestinal diseases were obtained from the UK Biobank study, the FinnGen study, and large consortia. Multivariable MR analyses were conducted for genetically determined LST with adjustment for MVPA and vice versa. We also performed multivariable MR with adju

SUBMITTER: Chen J 

PROVIDER: S-EPMC11004085 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature