Dataset Information

Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.

ABSTRACT:

Background

Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.

Methods

We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021-August 2021 in Jefferson County, Kentucky (USA). Our susceptible ( S ), vaccinated ( V ), variant-specific infected ( I1 and I2 ), recovered ( R ), and seropositive ( T ) model ( SVI2RT ) tracked prevalence longitudinally. This was related to wastewater concentration.

Results

Here we show the 64% county vaccination rate translate into about a 61% decrease in SARS-CoV-2 incidence. The estimated effect of SARS-CoV-2 Delta variant emergence is a 24-fold increase of infection counts, which correspond to an over 9-fold increase in wastewater concentration. Hospitalization burden and wastewater concentration have the strongest correlation (r = 0.95) at 1 week lag.

Conclusions

Our study underscores the importance of continuing environmental surveillance post-vaccine and provides a proof-of-concept for environmental epidemiology monitoring of infectious disease for future pandemic preparedness.

SUBMITTER: Holm RH

PROVIDER: S-EPMC11004132 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.

Holm Rochelle H RH Rempala Grzegorz A GA Choi Boseung B Brick J Michael JM Amraotkar Alok R AR Keith Rachel J RJ Rouchka Eric C EC Chariker Julia H JH Palmer Kenneth E KE Smith Ted T Bhatnagar Aruni A

Communications medicine 20240409 1

<h4>Background</h4>Despite wide scale assessments, it remains unclear how large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination affected the wastewater concentration of the virus or the overall disease burden as measured by hospitalization rates.<h4>Methods</h4>We used weekly SARS-CoV-2 wastewater concentration with a stratified random sampling of seroprevalence, and linked vaccination and hospitalization data, from April 2021-August 2021 in Jefferson County, Kentu ...[more]

PMID: 38594350

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Dataset Information

Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.

Background

Methods

Results

Conclusions

Publications

Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.

Similar Datasets

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