A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans.

ABSTRACT: Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements. We perform genome-wide association meta-analyses of 14 trace elements in up to 6564 Scandinavian whole blood samples, and genome-wide association studies of 43 trace elements in up to 2819 samples measured only in the Trøndelag Health Study (HUNT). We identify 11 novel genetic loci associated with blood concentrations of arsenic, cadmium, manganese, selenium, and zinc in genome-wide association meta-analyses. In HUNT, several genome-wide significan

SUBMITTER: Moksnes MR 

PROVIDER: S-EPMC11004147 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature