A mathematical model to assess the effects of COVID-19 on the cardiocirculatory system.

ABSTRACT: Impaired cardiac function has been described as a frequent complication of COVID-19-related pneumonia. To investigate possible underlying mechanisms, we represented the cardiovascular system by means of a lumped-parameter 0D mathematical model. The model was calibrated using clinical data, recorded in 58 patients hospitalized for COVID-19-related pneumonia, to make it patient-specific and to compute model outputs of clinical interest related to the cardiocirculatory system. We assessed, for each patient with a successful calibration, the statistical reliability of model outputs estimating the uncertainty intervals. Then, we performed a statistical analysis to compare healthy ranges and mean values (over patients) of reliable model outputs to determine which were significantly altered in CO

SUBMITTER: Tonini A 

PROVIDER: S-EPMC11004160 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature