Exploring the path to polio eradication: insights from consecutive seroprevalence surveys among Pakistani children.

ABSTRACT:

Introduction

After trivalent oral poliovirus vaccine (tOPV) cessation, Pakistan has maintained immunity to type 2 poliovirus by administering inactivated polio vaccine (IPV) in routine immunization, alongside monovalent OPV type 2 (mOPV2) and IPV in supplementary immunization activities (SIAs). This study assesses the change in poliovirus type 2 immunity after tOPV withdrawal and due to SIAs with mOPV2 and IPV among children aged 6-11 months.

Methods

Three cross-sectional sequential serological surveys were conducted in 12 polio high-risk areas of Pakistan. 25 clusters from each geographical stratum were selected utilizing probability proportional to size.

Results

Seroprevalence of type 2 poliovirus was 49%, with significant variation observed among surveyed areas; <3

SUBMITTER: Hussain I 

PROVIDER: S-EPMC11004230 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature