Probiotic supplementation for 24 weeks in patients with non-alcoholic steatohepatitis: the PROBILIVER randomized clinical trial.

ABSTRACT:

Background and aim

Considering the increasing prevalence of non-alcoholic steatohepatitis (NASH) and treatment gaps, this study aimed to evaluate the effect of probiotic supplementation on liver function markers, nutritional status, and clinical parameters.

Methods

This double-blind, randomized clinical trial (ClinicalTrials.gov ID: NCT0346782) included adult outpatients with biopsy-proven NASH. The intervention consisted of 24 weeks of supplementation with the probiotic mix Lactobacillus acidophilus (1 × 10⁹ CFU) + Lactobacillus rhamnosus (1 × 10⁹ CFU) + Lactobacillus paracasei (1 × 10⁹ CFU) + Bifidobacterium lactis (1 × 10⁹ CFU), or placebo, twice a day. The following parameters were evaluated: demogra

SUBMITTER: Silva-Sperb AS 

PROVIDER: S-EPMC11004384 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature