Unveiling potent Schiff base derivatives with selective xanthine oxidase inhibition: In silico and in vitro approach.

ABSTRACT: This research describes the synthesis by an environmentally-friendly method, microwave irradiation, development and analysis of three novel and one previously identified Schiff base derivative as a potential inhibitor of bovine xanthine oxidase (BXO), a key enzyme implicated in the progression of gout. Meticulous experimentation revealed that these compounds (10, 9, 4, and 7) have noteworthy inhibitory effects on BXO, with IC50 values ranging from 149.56 µM to 263.60 µM, indicating their good efficacy compared to that of the standard control. The validation of these results was further enhanced through comprehensive in silico studies, which revealed the pivotal interactions between the inhibitors and the catalytic sites of BXO, with a particular emphasis on the

SUBMITTER: Bellahcene F 

PROVIDER: S-EPMC11004395 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature