Cathepsin L promotes oesophageal squamous cell carcinoma development and may be associated with tumour-associated macrophages.

ABSTRACT:

Background

Oesophageal squamous cell carcinoma (ESCC) is a leading cause of cancer-related deaths worldwide because existing treatments are often insufficient. Therefore, new, reliable biomarkers must be identified. CTSL overexpression is closely associated with tumour progression and poor prognosis. However, the role and mechanism of CTSL as an oncogene in ESCC remain unclear.

Methods

Genome-wide association study (GWAS) data were used for Mendelian randomization analysis to investigate the possible relationships between CTSL and ESCC. The correlation between CTSL expression and prognosis was analysed using GEO, TCGA, and GEPIA data. We compared CTSL expression among the cell types using single-cell sequencing. Correlations between CTSL

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC11004422 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature