Secreted novel AID/APOBEC-like deaminase 1 (SNAD1) - a new important player in fish immunology.

ABSTRACT: The AID/APOBECs are a group of zinc-dependent cytidine deaminases that catalyse the deamination of bases in nucleic acids, resulting in a cytidine to uridine transition. Secreted novel AID/APOBEC-like deaminases (SNADs), characterized by the presence of a signal peptide are unique among all of intracellular classical AID/APOBECs, which are the central part of antibody diversity and antiviral defense. To date, there is no available knowledge on SNADs including protein characterization, biochemical characteristics and catalytic activity. We used various in silico approaches to define the phylogeny of SNADs, their common structural features, and their potential structural variations in fish species. Our analysis provides strong evidence of the universal presence of SNAD1 proteins/trans

SUBMITTER: Majewska AM 

PROVIDER: S-EPMC11004436 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature