Optimization of a tunable process for rapid production of calcium phosphate microparticles using a droplet-based microfluidic platform.

ABSTRACT: Calcium phosphate (CaP) biomaterials are amongst the most widely used synthetic bone graft substitutes, owing to their chemical similarities to the mineral part of bone matrix and off-the-shelf availability. However, their ability to regenerate bone in critical-sized bone defects has remained inferior to the gold standard autologous bone. Hence, there is a need for methods that can be employed to efficiently produce CaPs with different properties, enabling the screening and consequent fine-tuning of the properties of CaPs towards effective bone regeneration. To this end, we propose the use of droplet microfluidics for rapid production of a variety of CaP microparticles. Particularly, this study aims to optimize the steps of a droplet microfluidic-based production process, including droplet

SUBMITTER: Alaoui Selsouli Y 

PROVIDER: S-EPMC11004461 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature