Conserved patterns of sequence diversification provide insight into the evolution of two-component systems in Enterobacteriaceae.

ABSTRACT: Two-component regulatory systems (TCSs) are a major mechanism used by bacteria to sense and respond to their environments. Many of the same TCSs are used by biologically diverse organisms with different regulatory needs, suggesting that the functions of TCS must evolve. To explore this topic, we analysed the amino acid sequence divergence patterns of a large set of broadly conserved TCS across different branches of Enterobacteriaceae, a family of Gram-negative bacteria that includes biomedically important genera such as Salmonella, Escherichia, Klebsiella and others. Our analysis revealed trends in how TCS sequences change across different proteins or functional domains of the TCS, and across different lineages. Based on these trends, we identified individual TC

SUBMITTER: Barretto LAF 

PROVIDER: S-EPMC11004495 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature