Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma.

ABSTRACT:

Background

Increased age is a strong and unfavorable prognostic factor for patients with glioblastoma (GBM). However, the relationships between stratified patient age, comorbidities, and medications have yet to be explored in GBM patient survival analyses.

Objective

To evaluate co-morbid conditions, tumor-related symptoms, medication prescriptions, and subject age for patients with GBM and to establish potential targets for prospective studies.

Methods

Electronic health records for 565 patients with IDHwt GBM were evaluated at a single center between January 1, 2000 and August 9, 2021 were retrospectively assessed. Data were stratified by MGMT promoter methylation status when available and were used to construct multivariable time-dependent cox models and intra-cohort

SUBMITTER: Rabin EE 

PROVIDER: S-EPMC11004500 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature