Identification of survival related key genes and long-term survival specific differentially expressed genes related key miRNA network of primary glioblastoma.

ABSTRACT: Primary glioblastoma(pGBM) is the most malignant tumor of the central nervous system. Radiotherapy, chemotherapy and surgical treatment have little effect on the survival of pGBM patients. The prognosis is often poorly once the tumor recurs. It is urgent to develop new therapies for patients. In recent years, studies have been clarified that miRNA have a powerful regulating effect on the genes. However, the main group of miRNAs in regulating long-term survival specific related genes of pGBM is still unclear. Given that the survival period of most glioma patients is relatively short, studying long-term survival patients with pGBM is of great value for this disease. Our study aim to identify key miRNAs with long-term survival related genes present in pGBM and uncover their potential mechanis

SUBMITTER: Zhou L 

PROVIDER: S-EPMC11004527 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature