Associations of education attainment with gestational diabetes mellitus and the mediating effects of obesity: A Mendelian randomization study.

ABSTRACT: We aim to assess the causal association between educational attainment and gestational diabetes mellitus, and the mediating effect of obesity on this association. We estimated the causal effects of educational attainment on gestational diabetes mellitus using European ancestry genome-wide association study summary data with two-sample univariate Mendelian randomization (UVMR) approach. Two-stage Mendelian randomization analysis was performed to assess the potential mediating role of obesity traits in this association and to calculate the mediating proportion. UVMR analysis demonstrated that higher educational attainment was associated with a reduced risk of GDM (OR 0.76, 95% CI 0.67-0.86; p < 0.01). EA has also been associated with decreased obesity in women. Mediation Mendelian randomizat

SUBMITTER: Wang X 

PROVIDER: S-EPMC11004574 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature