Stratifying Disease Progression in Patients With Cardiac ATTR Amyloidosis.

ABSTRACT:

Background

Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive cardiomyopathy. The clinical course varies among individuals and there are no established measures to assess disease progression.

Objectives

The goal of this study was to assess the prognostic importance of an increase in N-terminal pro-B-type natriuretic peptide (NT-proBNP) and outpatient diuretic intensification (ODI) as markers of disease progression in a large cohort of patients with ATTR-CA.

Methods

We evaluated landmark survival analysis based on worsening of NT-proBNP and requirement for ODI between time of diagnosis and a 1-year visit, and subsequent mortality in 2,275 patients with ATTR-CA from 7 specialist centers. The variables were developed in the National Amyloidosis Centre (NAC) coh

SUBMITTER: Ioannou A 

PROVIDER: S-EPMC11004588 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature