Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability.

ABSTRACT:

Importance

Several studies suggest that acetaminophen (paracetamol) use during pregnancy may increase risk of neurodevelopmental disorders in children. If true, this would have substantial implications for management of pain and fever during pregnancy.

Objective

To examine the associations of acetaminophen use during pregnancy with children's risk of autism, attention-deficit/hyperactivity disorder (ADHD), and intellectual disability.

Design, setting, and participants

This nationwide cohort study with sibling control analysis included a population-based sample of 2 480 797 children born in 1995 to 2019 in Sweden, with follow-up through December 31, 2021.

Exposure

Use of acetaminophen during pregnancy prospectively recorded from antenatal and prescription record

SUBMITTER: Ahlqvist VH 

PROVIDER: S-EPMC11004836 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature