Metabolite Stability in Archived Neonatal Dried Blood Spots Used for Epidemiologic Research.

ABSTRACT: Epidemiologic studies of low-frequency exposures or outcomes using metabolomics analyses of neonatal dried blood spots (DBS) often require assembly of samples with substantial differences in duration of storage. Independent assessment of stability of metabolites in archived DBS will enable improved design and interpretation of epidemiologic research utilizing DBS. Neonatal DBS routinely collected and stored as part of the California Genetic Disease Screening Program between 1983 and 2011 were used. The study population included 899 children without cancer before age 6 years, born in California. High-resolution metabolomics with liquid-chromatography mass spectrometry was performed, and the relative ion intensities of common metabolites and selected xenobiotic metabolites of nicotine (cotin

SUBMITTER: He D 

PROVIDER: S-EPMC11004922 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature