Hyperbaric oxygen therapy promotes the browning of white fat and contributes to the healing of diabetic wounds.

ABSTRACT: Non-healing wounds are one of the chronic complications of diabetes and have remained a worldwide challenge as one of the major health problems. Hyperbaric oxygen (HBO) therapy is proven to be very successful for diabetic wound treatment, for which the molecular basis is not understood. Adipocytes regulate multiple aspects of repair and may be therapeutic for inflammatory diseases and defective wound healing associated with aging and diabetes. Endothelial cell-derived extracellular vesicles could promote wound healing in diabetes. To study the mechanism by which HBO promotes wound healing in diabetes, we investigated the effect of HBO on fat cells in diabetic mice. A diabetic wound mouse model was established and treated with HBO. Haematoxylin and eosin (H&E) staining and immunofluorescenc

SUBMITTER: Yin Y 

PROVIDER: S-EPMC11005105 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature