Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals.

ABSTRACT:

Background

Individuals on the preclinical Alzheimer's continuum, particularly those with both amyloid and tau positivity (A + T +), display a rapid cognitive decline and elevated disease progression risk. However, limited studies exist on brain atrophy trajectories within this continuum over extended periods.

Methods

This study involved 367 ADNI participants grouped based on combinations of amyloid and tau statuses determined through cerebrospinal fluid tests. Using longitudinal MRI scans, brain atrophy was determined according to the whole brain, lateral ventricle, and hippocampal volumes and cortical thickness in AD-signature regions. Cognitive performance was evaluated with the Preclinical Alzheimer's Cognitive Composite (PACC). A generalized linear mixed-effects model wa

SUBMITTER: Fujishima M 

PROVIDER: S-EPMC11005141 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature