Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.

ABSTRACT: Ferroptosis is a newly identified iron-dependent form of death that is becoming increasingly recognized as a promising avenue for cancer therapy. N6-methyladenosine (m⁶A) is the most abundant reversible methylation modification in mRNA contributing to tumorigenesis. However, the crucial role of m⁶A modification in regulating ferroptosis during colorectal cancer (CRC) tumorigenesis remains elusive. Herein, we find that m⁶A modification is increased during ferroptotic cell death and correlates with the decreased m⁶A demethylase fat mass and obesity-associated protein (FTO) expression. Functionally, we demonstrate that suppressing FTO significantly induces CRC ferroptotic cell death, as well as enhancing CRC cell sensitivity to ferroptosis inducer (

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC11005233 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature