Distinct actions of testicular endocrine and lumicrine signaling on the proximal epididymal transcriptome.

ABSTRACT: The epididymal function and gene expression in mammals are under the control of the testis. Sex steroids are secreted from the testis and act on the epididymis in an endocrine manner. There is another, non-sex steroidal secreted signaling, named lumicrine signaling, in which testis-derived secreted proteins go through the male reproductive tract and act on the epididymis. The effects of such multiple regulations on the epididymis by the testis have been investigated for many genes. The recent development of high-throughput next-generation sequencing now enables us a further comparative survey of endocrine and lumicrine action-dependent gene expression. In the present study, testis-derived endocrine and lumicrine actions on epididymal gene expression were comparatively investigated by RNA-s

SUBMITTER: Kiyozumi D 

PROVIDER: S-EPMC11005294 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature