Transcriptome fine-mapping in Fusobacterium nucleatum reveals FoxJ, a new σ^E-dependent small RNA with unusual mRNA activation activity.

ABSTRACT: The oral commensal Fusobacterium nucleatum can spread to extra-oral sites, where it is associated with diverse pathologies, including pre-term birth and cancer. Due to the evolutionary distance of F. nucleatum to other model bacteria, we lack a deeper understanding of the RNA regulatory networks that allow this bacterium to adapt to its various niches. As a first step in that direction, we recently showed that F. nucleatum harbors a global stress response governed by the extracytoplasmic function sigma factor, σ^E, which displays a striking functional conservation with Proteobacteria and includes a noncoding arm in the form of a regulatory small RNA (sRNA), FoxI. To search for putative additional σ^E-dependent sRNAs, we comprehensively mapped the 5'

SUBMITTER: Ponath F 

PROVIDER: S-EPMC11005410 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature