Outcomes of and indications for renal transplantation in patients with von Hippel Lindau disease.

ABSTRACT:

Introduction and objective

Von Hippel-Lindau (VHL) is a hereditary cancer syndrome characterized by bilateral, multifocal renal masses. The cumulative impact of extirpative surgery can depreciate renal function and render patients anephric. In the larger end-stage renal disease population, renal transplant offers both excellent quality of life and functional renal replacement. This case control study aims to examine and compare oncologic and functional outcomes of patients who have undergone renal transplant as renal replacement therapy (RRT) to those who remain anephric.

Methods

Patient charts were retrospectively reviewed of patients with germline testing confirmed VHL between 1980 and 2022 for transplant, all prior surgical history (within and outside the NCI), renal func

SUBMITTER: Antony MB 

PROVIDER: S-EPMC11005910 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature