CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction.

ABSTRACT:

Background

Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. Since the geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes, we investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice.

Methods

Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months. Blood, adipose tissue, and liver were analyzed for glucose, lipids, and protein markers of energy metabolism.

Results

The CMS121 diet induced a 40% decrease in body weight gain and improved both glucose and l

SUBMITTER: Dafre AL 

PROVIDER: S-EPMC11006478 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature