A patterned human neural tube model using microfluidic gradients.

ABSTRACT: The human nervous system is a highly complex but organized organ. The foundation of its complexity and organization is laid down during regional patterning of the neural tube, the embryonic precursor to the human nervous system. Historically, studies of neural tube patterning have relied on animal models to uncover underlying principles. Recently, models of neurodevelopment based on human pluripotent stem cells, including neural organoids^1-5 and bioengineered neural tube development models^6-10, have emerged. However, such models fail to recapitulate neural patterning along both rostral-caudal and dorsal-ventral axes in a three-dimensional tubular geometry, a hallmark of neural tube development. Here we report a human pluripotent stem cell-based, microfluidic neural tu

SUBMITTER: Xue X 

PROVIDER: S-EPMC11006583 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature