Force-controlled release of small molecules with a rotaxane actuator.

ABSTRACT: Force-controlled release of small molecules offers great promise for the delivery of drugs and the release of healing or reporting agents in a medical or materials context^1-3. In polymer mechanochemistry, polymers are used as actuators to stretch mechanosensitive molecules (mechanophores)⁴. This technique has enabled the release of molecular cargo by rearrangement, as a direct^5,6 or indirect^7-10 consequence of bond scission in a mechanophore, or by dissociation of cage¹¹, supramolecular¹² or metal complexes^13,14, and even by 'flex activation'^15,16. However, the systems described so far are limited in the diversity and/or quantity of the molecules released per stretching event^1,2. This is due

SUBMITTER: Chen L 

PROVIDER: S-EPMC11006608 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature