Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis.

ABSTRACT: Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to changing environments, yet the concept of transcriptional plasticity (TP) - the variability of gene expression in response to environmental changes - remains largely unexplored. In this study, we investigate the genome-wide TP profiles of Mycobacterium tuberculosis (Mtb) genes by analyzing 894 RNA sequencing samples derived from 73 different environmental conditions. Our data reveal that Mtb genes exhibit significant TP variation that correlates with gene function and gene essentiality. We also find that critical genetic features, such as gene length, GC content, and operon size independently impose constraints on TP, beyond trans-regulation. By extending our analysis to include two other Mycobac

SUBMITTER: Bei C 

PROVIDER: S-EPMC11006872 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature