Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naive first episode psychosis patients.

ABSTRACT: Human connectome studies have provided abundant data consistent with the hypothesis that functional dysconnectivity is predominant in psychosis spectrum disorders. Converging lines of evidence also suggest an interaction between dorsal anterior cingulate cortex (dACC) cortical glutamate with higher-order functional brain networks (FC) such as the default mode (DMN), dorsal attention (DAN), and executive control networks (ECN) in healthy controls (HC) and this mechanism may be impaired in psychosis. Data from 70 antipsychotic-medication naïve first-episode psychosis (FEP) and 52 HC were analyzed. 3T Proton magnetic resonance spectroscopy (1H-MRS) data were acquired from a voxel in the dACC and assessed correlations (positive FC) and anticorrelations (negative FC) of the DMN, DAN, and ECN. W

SUBMITTER: Maximo JO 

PROVIDER: S-EPMC11006887 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature