Salmonella exploits membrane reservoirs for invasion of host cells.

ABSTRACT: Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection¹. The effectors modulate host cell machinery to drive uptake of the bacteria into vacuoles, where they can establish an intracellular replicative niche. A remarkable feature of Salmonella invasion is the formation of actin-rich protuberances (ruffles) on the host cell surface that contribute to bacterial uptake. However, the membrane source for ruffle formation and how these bacteria regulate membrane mobilization within host cells remains unclear. Here, we show that Salmonella exploits membrane reservoirs for the generation of invasion ruffles. The reservoirs are pre-existing tubular compartments associated with the plasma membrane (PM) and are formed thr

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11006906 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature