Optimization of flavanonols heterologous biosynthesis in Streptomyces albidoflavus, and generation of auronols.

ABSTRACT: Aromadendrin and taxifolin are two flavanonols (derived from the precursor naringenin) displaying diverse beneficial properties for humans. The carbon skeleton of these flavonoids may be transformed by the human gastrointestinal microbiota into other compounds, like auronols, which exert different and interesting biological activities. While research in flavonoids has become a certainly extensive field, studies about auronols are still scarce. In this work, different versions of the key plant enzyme for flavanonols biosynthesis, The flavanone 3-hydroxylase (F3H), has been screened for selecting the best one for the de novo production of these compounds in the bacterial factory Streptomyces albidoflavus UO-FLAV-004-NAR, a naringenin overproducer strain. This screening has rend

SUBMITTER: Magadan-Corpas P 

PROVIDER: S-EPMC11007074 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature