Comprehensive analysis of brain injury parameters in a preclinical porcine model of acute liver failure.

ABSTRACT:

Introduction

Acute liver failure (ALF) is defined as acute loss of liver function leading to hepatic encephalopathy associated with a high risk of patient death. Brain injury markers in serum and tissue can help detect and monitor ALF-associated brain injury. This study compares different brain injury parameters in plasma and tissue along with the progression of ALF.

Method

ALF was induced by performing an 85% liver resection. Following the resection, animals were recovered and monitored for up to 48 h or until reaching the predefined endpoint of receiving standard medical therapy (SMT). Blood and serum samples were taken at T_baseline, T₂₄, and upon reaching the endpoint (T_end). Control animals were euthanized by exsanguination following plas

SUBMITTER: Felgendreff P 

PROVIDER: S-EPMC11007081 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature