Down-sampling in diffusion MRI: a bundle-specific DTI and NODDI study.

ABSTRACT:

Introduction

Multi-shell diffusion Magnetic Resonance Imaging (dMRI) data has been widely used to characterise white matter microstructure in several neurodegenerative diseases. The lack of standardised dMRI protocols often implies the acquisition of redundant measurements, resulting in prolonged acquisition times. In this study, we investigate the impact of the number of gradient directions on Diffusion Tensor Imaging (DTI) and on Neurite Orientation Dispersion and Density Imaging (NODDI) metrics.

Methods

Data from 124 healthy controls collected in three different longitudinal studies were included. Using an in-house algorithm, we reduced the number of gradient directions in each data shell. We estimated DTI and NODDI measures on six white matter bundles clinically relevant

SUBMITTER: Spagnolo F 

PROVIDER: S-EPMC11007093 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature