Causal association between air pollution and autoimmune diseases: a two-sample Mendelian randomization study.

ABSTRACT:

Background

In recent years, an increasing number of observational studies have reported the impact of air pollution on autoimmune diseases (ADs). However, no Mendelian randomization (MR) studies have been conducted to investigate the causal relationships. To enhance our understanding of causality, we examined the causal relationships between particulate matter (PM) and nitrogen oxides (NO_x) and ADs.

Methods

We utilized genome-wide association study (GWAS) data on PM and NO_x from the UK Biobank in European and East Asian populations. We also extracted integrated GWAS data from the Finnish consortium and the Japanese Biobank for two-sample MR analysis. We employed inverse variance weighted (IVW) analysis to assess the causal relationship between PM and NO

SUBMITTER: Hu H 

PROVIDER: S-EPMC11007215 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature