Genome-Wide Association Studies of Diarrhea Frequency and Duration in the First Year of Life in Bangladeshi Infants.

ABSTRACT:

Background

Diarrhea is the second leading cause of death in children under 5 years old worldwide. Known diarrhea risk factors include sanitation, water sources, and pathogens but do not fully explain the heterogeneity in frequency and duration of diarrhea in young children. We evaluated the role of host genetics in diarrhea.

Methods

Using 3 well-characterized birth cohorts from an impoverished area of Dhaka, Bangladesh, we compared infants with no diarrhea in the first year of life to those with an abundance, measured by either frequency or duration. We performed a genome-wide association analysis for each cohort under an additive model and then meta-analyzed across the studies.

Results

For diarrhea frequency, we identified 2 genome-wide significant loci associated wi

SUBMITTER: Munday RM 

PROVIDER: S-EPMC11007397 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature