Revealing the mechanism of central pain hypersensitivity in primary dysmenorrhea: evidence from neuroimaging.

ABSTRACT:

Background

Primary dysmenorrhea (PDM) is the most common problem in menstruating women. A number of functional magnetic resonance imaging (fMRI) study have revealed that the brain plays a crucial role in the pathophysiology of PDM. However, these results have been inconsistent, and there is a lack of a comprehensive fMRI study to clarify the onset and long-term effects of PDM. The aim of this study was thus to investigate the onset and long-term effects of PDM in a cohort of patients with PDM.

Methods

This study employed a cross-sectional design with prospective data collection, in which 25 patients with PDM and 20 healthy controls (HCs) were recruited. The patients with PDM underwent fMRI scans both during the PDM during the pain phase (PDM-P) and nonpain phase (PDM-NP). Th

SUBMITTER: Jin P 

PROVIDER: S-EPMC11007516 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature