Deep-targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma.

ABSTRACT:

Aims

To investigate the key factors influencing glioma progression and the emergence of treatment resistance by examining the intrinsic connection between mutations in DNA damage and repair-related genes and the development of chemoresistance in gliomas.

Methods

We conducted a comprehensive analysis of deep-targeted gene sequencing data from 228 glioma samples. This involved identifying differentially mutated genes across various glioma grades, assessing their functions, and employing I-TASSER for homology modeling. We elucidated the functional changes induced by high-frequency site mutations in these genes and investigated their impact on glioma progression.

Results

The analysis of sequencing mutation results of deep targeted genes in integration revealed that ARID1A

SUBMITTER: Xiao M 

PROVIDER: S-EPMC11007544 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature