Do beta-blockers reduce negative intrusive thoughts and anxiety in cancer survivors? - An emulated trial.

ABSTRACT:

Background

High rates of negative intrusive thoughts have been reported among cancer patients. Prevalent users of beta-blocker therapy have reported lower levels of cancer related intrusive thoughts than non-user. The aim of this study is to investigate if initiation of beta-blocker therapy reduces the prevalence and severity of intrusive thoughts (co-primary endpoints) and the prevalence of anxiety, depressed mood, and low quality of life (secondary endpoints) in cancer survivors.

Methods

Data on patient-reported outcomes from three cohort studies of Swedish patients diagnosed with colon, prostate or rectal cancer were combined with data on beta-blocker prescriptions retrieved from the Swedish Prescribed Drug Register. Two randomized controlled trials were emulated. Trial 1

SUBMITTER: Ehrencrona C 

PROVIDER: S-EPMC11007941 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature