Isolation and genetic characteristics of Novel H4N1 Avian Influenza viruses in ChongQing, China.

ABSTRACT:

Background

Avian influenza viruses (AIVs) constitute significant zoonotic pathogens encompassing a broad spectrum of subtypes. Notably, the H4 subtype of AIVs has a pronounced ability to shift hosts. The escalating prevalence of the H4 subtype heightens the concern for its zoonotic potential, signaling an urgent need for vigilance.

Methods

During the period from December 2021 to November 2023, we collected AIV-related environmental samples and assessed them using a comprehensive protocol that included nucleic acid testing, gene sequencing, isolation culture, and resequencing.

Results

In this study, a total of 934 environmental samples were assessed, revealing a remarkably high detection rate (43.66%, 289/662) of AIV in the live poultry market. Notably, the H4N1 subtyp

SUBMITTER: He J 

PROVIDER: S-EPMC11008002 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature