Radical versus Local Surgical Excision for Early Rectal Cancer: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Radical excision (RE) for rectal cancer carries a higher risk of mortality and morbidity, while local excision (LE) could decrease these postoperative risks. However, the long-term benefit of LE is still debatable.

Aim

To study the effectiveness of LE versus RE in T1 and T2 rectal cancer.

Methods

A systematic review and meta-analysis was conducted using key databases like PubMed and ClinicalTrials.gov. Only cohort studies and randomized controlled trials were included. RevMan 5.4 tool was used for data analysis. Both clinical and statistical heterogeneity of the studies were assessed, and I² >75% was considered as highly heterogeneous. The primary outcomes being measured were 5-year overall survival (OS) and 5-year disease free survival (DFS). A

SUBMITTER: El-Nakeep S 

PROVIDER: S-EPMC11008054 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature