Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association.

ABSTRACT:

Background

Frailty, a clinical syndrome intricately linked with the aging process, stands as a harbinger of numerous adverse outcomes, most notably mortality. This study aimed to elucidate the association between serum α-klotho concentration and mortality patterns, including all-cause and cause-specific mortality, in patients with frailty.

Methods

The study employed Cox proportional hazard models, smoothed curve fitting, and supplementary analyses, encompassing threshold effect analysis, subgroup and sensitivity analyses, to explore the relationship between α-klotho levels and mortality, including all-cause, CVD, and cancer-related mortality.

Results

Among the 2,608 frail individuals (mean age: 60.78 [SD 10.48] years; 59.89% female), the mortality stood at 25.35% duri

SUBMITTER: Luo H 

PROVIDER: S-EPMC11008069 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature