Genistin: A Novel Estrogen Analogue Targeting ERβ to Alleviate Thrombocytopenia.

ABSTRACT: Thrombocytopenia, a prevalent hematologic challenge, correlates directly with the mortality of numerous ailments. Current therapeutic avenues for thrombocytopenia are not without limitations. Here, we identify genistin, an estrogen analogue, as a promising candidate for thrombocytopenia intervention, discovered through AI-driven compound library screening. While estrogen's involvement in diverse biological processes is recognized, its role in thrombopoiesis remains underexplored. Our findings elucidate genistin's ability to enhance megakaryocyte differentiation, thereby augmenting platelet formation and production. In vivo assessments further underscore genistin's remedial potential against radiation-induced thrombocytopenia. Mechanistically, genistin's efficacy is attributed to its

SUBMITTER: Tang X 

PROVIDER: S-EPMC11008259 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature