Evaluation of partial volume correction and analysis of longitudinal [¹⁸F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models.

ABSTRACT:

Purpose

We evaluated the impact of partial volume correction (PVC) methods on the quantification of longitudinal [¹⁸F]GTP1 tau positron-emission tomography (PET) in Alzheimer's disease and the suitability of describing the tau pathology burden temporal trajectories using linear mixed-effects models (LMEM).

Methods

We applied van Cittert iterative deconvolution (VC), 2-compartment, and 3-compartment, and the geometric transfer matrix plus region-based voxelwise methods to data acquired in an Alzheimer's disease natural history study over 18 months at a single imaging site. We determined the optimal PVC method by comparing the standardized uptake value ratio change (%ΔSUVR) between diagnostic and tau burden-level groups and the longitudinal repeatability derived fro

SUBMITTER: Sanabria Bohorquez SM 

PROVIDER: S-EPMC11008283 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature