Circulating plasma cells as a predictive biomarker in Multiple myeloma: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Circulating plasma cells (CPCs) are defined by the presence of peripheral blood clonal plasma cells, which would contribute to the progression and dissemination of multiple myeloma (MM). An increasing number of studies have demonstrated the predictive potential of CPCs in the past few years. Therefore, there is a growing need for an updated meta-analysis to identify the specific relationship between CPCs and the prognosis of MM based on the current research status.

Methods

The PubMed, Embase, and Cochrane Library databases were screened to determine eligible studies from inception to November 5, 2023. Publications that reported the prognostic value of CPCs in MM patients were included. Hazard ratios (HRs) with 95% confidence intervals (CIs) of overall survival (OS

SUBMITTER: Li Q 

PROVIDER: S-EPMC11008311 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature