PH-responsive niosome-based nanocarriers of antineoplastic agents.

ABSTRACT: Differences in pH between the tumour interstitium and healthy tissues can be used to induce conformational changes in the nanocarrier structure, thereby triggering drug release at the desired site. In the present study, novel pH-responsive nanocarriers were developed by modifying conventional niosomes with hexadecyl-poly(acrylic acid)_n copolymers (HD-PAA_n). Niosomal vesicles were prepared by the thin film hydration method using Span 60, Span 60/Tween 60 and cholesterol as main constituents, and HD-PAA modifiers of different concentrations (0.5, 1, 2.5, 5 mol%). Next, two model substances, a water-soluble fluorescent dye (calcein) and a hydrophobic agent with pronounced antineoplastic activity (curcumin), were loaded in the aqueous core and hydrophobic me

SUBMITTER: Gugleva V 

PROVIDER: S-EPMC11008427 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature